Our results have important therapeutic implications, suggesting an approach to enhancing antiretroviral activity through pharmacologic interventions that may prolong the drug-susceptible state and opening the potential for drugs that may boost efficacy of antiretroviral drugs through modification of viral life-cycle kinetics.
To boost efficacy, many of the second-generation anti-CD20 mAbs have increased binding affinity to the Fc receptor on B cells and increased complement-dependent cytotoxicity (CDC) and/or antibody-dependent cellular cytotoxicity (ADCC) [8].
Although the application of only OECs has shown promise in the promotion of recovery after SCI, combinatorial approaches have also been utilized in order to boost efficacy.
It would be pertinent in future to test the combination of envelope glycoprotein-based and T cell-based vaccines for potential additive or synergistic effects to boost efficacy.
Moreover, the immune-boosting efficacy of calcarea carbonica was found to be comparable to the established immune-modulating cytokine, IL2 [ 17, 18].
That same year, he announced what is probably the biggest gift ever made to benefit public education, $500 million, spread over five years and among several institutions and organizations bent on boosting the efficacy of public schools, the bulk to be spent in urban areas, including New York, Chicago and Los Angeles.
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These studies underline that SVF may be a promising adjuvant population boosting the efficacy of conventional AFT.
Since 2002, more than a dozen candidate vaccines have entered into clinical testing (3), with the aim of boosting the efficacy of BCG or replacing it altogether.
Despite their lack of single-agent activity, anti-angiogenic agents have shown favourable effects in boosting the efficacy of standard chemotherapy regimens in different tumour types (Ellis and Hicklin, 2008).
Whether or not these cytokine responses can or should be enhanced further to boost the efficacy of an HIV-1 T-cell vaccine remains to be seen.
