Following the booster loft of the second stage and payload on its orbital trajectory, SpaceX conducted a successful flight test on the spent first stage.
During this time an accelerated vaccination schedule was in place, but it lacked requirement of a booster in the second year of life.
"But there are advantages in having very similar configurations on the boosters of the first and second stage.
For the countries that have included MenC vaccine in their programme, the most commonly used vaccination schedules are 2 doses in first year of life and a booster in the second year of life or 1 dose in the second year of life with possibly an additional booster later in life.
SpaceX also attempted to land the first stage booster of the rocket – the first in a new Block 5 class – back on Earth about eight minutes after launching at Landing Zone 1 in Cape Canaveral.
Much of the clinical data during the development of DTPa-HBV-IPV/Hib were obtained in studies that employed a 3-dose primary vaccination schedule with a booster in the second year of life.
In several European countries is used, to date, the so-called 3 + 1 schedule, which includes a 3-dose primary series plus a booster in the second year of life.
25 Following MenC conjugate vaccination in infancy there is waning of post-vaccination functional antibody titres by the 12th month of life, which has led to the introduction of the booster dose in the second year of life in the UK schedule.
Sera collected from mice after four weeks of immunization, with a booster at the second week, were used in ELISA to score for antibody response against the recombinant PE25, PPE41 and PE25/PPE41 protein complex.
Children under 3-4 years of age were also relatively well protected as a consequence of the booster dose in the second year of life.
A 2 + 1 schedule has been demonstrated to be effective in Europe and North America administered at 2 and 4 or 3 and 5 months of age with a booster dose in the second year of life [ 7, 10, 24, 25].
