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A more recent development of brachytherapy is known as high dose rate (HDR) brachytherapy with Ir [ 76], which provides a boosted dose of radiation following EBRT [ 78].
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The first proof-of-concept trial for DRV was a 14-day multicenter trial of 3 boosted doses of DRV/ritonavir (DRV/r) (300/100 mg twice daily, 900/100 mg daily, and 600/100 mg twice daily) compared to a standard optimized background regimen.
A boosting dose of emulsified EV71/CVA16 bivalent vaccine candidate was found to be necessary to achieve high seroconversion of CVA16-specific neutralizing antibody responses.
3 weeks after initial immunizations, a boosting dose of 5 × 10 pfu of Δ gD−/+gD−1 or VD60 cell lysate was administered.
The initial large-field target volume consisted of the primary tumour, mediastinum, and involved hilar of supraclavicular nodes (total dose, 40 Gy), and boost dose of 20 Gy was delivered to a volume that consisted of the primary tumour and involved nodes.
A recent study evaluated patients receiving PI-based ARV therapy, with or without RTV co-administration [ 9]; the risk of developing hepatotoxicity was similar across the PIs evaluated and a boosting dose of RTV was associated with a much lower risk than was observed with therapeutic RTV dosing [ 9].
Secondary immune responses were assessed after the administration of an immunizing dose (5×104 pfu) of virus and a boosting dose (106 pfu) of virus.
Moreover, we obtained a response specific for 33BF peptide of a magnitude of 90 SFC/million when animals received a boost dose of the VVEnvBF four times higher (4×107 PFU/animal), in which case the responses evaluated against the other peptides were saturated (non-countable) (data not shown).
A median boost dose of 9.2 Gy (4 20 Gy) was administered to patients with persistent disease at the primary site.
The authors concluded that a boost dose of 16 Gy led to improved local control of lesions in the boost group, but no benefits in improving overall survival.
A boost dose of 10 to 16 Gy to the gross tumour volume (defined by FDG PET after induction chemotherapy) was given in the same dose fractionation.
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