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DNA prime and recombinant fowlpox virus (rFPV) boost vaccines were designed to express multiple HIV or SIV antigens for use in human clinical trials and in pre-clinical trials in macaques.
As it is believed that BCG will continue to be used as a primary vaccine for human immunization and that effective boost vaccines need to be identified, our current finding that Ad vaccine-based boosting is effective to improve protection to BCG-primed guinea pigs, is significant.
We proposed that boost vaccines should induce long-lived functional and phenotypic changes to T cells primed by Bacille Calmette Guerin (BCG) and/or natural exposure to mycobacteria.
The success of heterologous boost vaccines may depend on the modulation of the existing mycobacteria-specific T-cell repertoire to possess more "favorable" functional characteristics, rather than inducing de novo T-cell responses.
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We propose two minimum criteria for a potentially successful heterologous vaccination strategy: (1) the boost vaccine should modify or reprogram the T-cell response to display different functional and/or phenotypic characteristics to the prevaccination response; (2) the induced T-cell response should be long lived.
Although HPV L1 antibodies were induced in all immunized macaques, weak antibody or T cell responses to the chimeric SHIV antigens were detected only in animals receiving the DNA prime/HPV SHIV VLP boost vaccine regimen.
These IFITMs exist in many other species, and Elledge suggests that removing them from chicken embryos or animal cells that are used to make influenza vaccines may greatly boost vaccine production by allowing the virus to make more copies of itself.
We have molecularly determined the HLA class II DR and DQ gene, allele and haploype profiles in HIV-1 negative ethnic Thai recipients of an HIV-1 prime boost vaccine regimen, designed to induce neutralizing antibody (NAb) responses to HIV-1 CRF01_AE.
The plan helps boost vaccine coverage by cutting the need for repeated visits to health clinics, which are often difficult to get to in poor, rural areas.
There are three major types of heterologous boost vaccine candidates: protein-, plasmiDNANA- and viral-based vaccines.
Recombinant adenovirus-vectored (Ad) tuberculosis (TB) vaccine platform has demonstrated great potential to be used either as a stand-alone or a boost vaccine in murine models.
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