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We propose two minimum criteria for a potentially successful heterologous vaccination strategy: (1) the boost vaccine should modify or reprogram the T-cell response to display different functional and/or phenotypic characteristics to the prevaccination response; (2) the induced T-cell response should be long lived.
Keele, B. F. et al. Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys.
Although HPV L1 antibodies were induced in all immunized macaques, weak antibody or T cell responses to the chimeric SHIV antigens were detected only in animals receiving the DNA prime/HPV SHIV VLP boost vaccine regimen.
We have molecularly determined the HLA class II DR and DQ gene, allele and haploype profiles in HIV-1 negative ethnic Thai recipients of an HIV-1 prime boost vaccine regimen, designed to induce neutralizing antibody (NAb) responses to HIV-1 CRF01_AE.
Could California Law To Boost Vaccine Uptake End Up Reducing It? Ah, California.
A DNA prime-modified vaccinia virus Ankara (MVA) boost vaccine has proven to be potent in eliciting antibody responses.
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DNA prime and recombinant fowlpox virus (rFPV) boost vaccines were designed to express multiple HIV or SIV antigens for use in human clinical trials and in pre-clinical trials in macaques.
Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer.
Our findings highlight the potential of HIV-DNA prime HIV-MVA boost vaccines for induction of functional antibody responses and suggest this vaccine regimen and ADCC studies as potentially important new avenues in HIV vaccine development.Controlled-Trials ISRCTN90053831 The Pan African Clinical Trials Registry ATMR2009040001075080 (currently PACTR2009040001075080).
As it is believed that BCG will continue to be used as a primary vaccine for human immunization and that effective boost vaccines need to be identified, our current finding that Ad vaccine-based boosting is effective to improve protection to BCG-primed guinea pigs, is significant.
Antigen-specific antibody concentrations exceeding 100 μg/ml have been attained in humans by other malaria vaccines including RTS,S and those targeting PfAMA1 (Kester et al., 2009; Spring et al., 2009), but long-term maintenance of such high-level responses may be challenging, particularly if P. falciparum infection does not appreciably boost vaccine-induced anti-PfRH5 responses.
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