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The possibility that CC-5013 may boost previously induced immunity is suggested by the fact that five patients with minor responses and static disease had previously been given some form of immunotherapy, such as melanoma peptides or IL-2.
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Another option is to express Mtb antigens in the modified vaccinia virus Ankara (MVA) as a vaccine to boost subjects previously immunised with BCG [6].
Compared to the DNA prime-rAd boost approach previously reported [21], the single-dose rAd strategy reported here has the advantage of a streamlined vaccination protocol.
Combined IMRT and C12-heavy ion boost has previously been established as a treatment of choice in skull-base adenoid cystic carcinoma.
Rabbit mAb R53 is one of the mAbs that we recently generated from a New Zealand white rabbit that was immunized with JR-FL DNA prime, followed by a homologous protein boost, as previously reported.
This certainly boosted his previously lukewarm support.
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DOI: http://dx.doi.org/10.7554/eLife.06467.017 To check and compare the FDC network loading of the two gp120 preparations we waited 3 weeks after boosting mice previously immunized with 293F gp120 and injected both 293F and CHO-S expressed gp120 near the inguinal LN.
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