The key strength of this strategy is that greater levels of immunity are established by heterologous prime-boost in which the antigen is applied via different routes and immunization sites [ 34].
For ML, RAD-T then uses an alternating decision tree (ADTree) [ 241, 242], an extension of the classical decision tree that integrates across multiple paths in the tree and makes use of boosting, in which multiple weak learners are used to build a single strong one.
This paper proposes an improved Multilevel Boost Converter, also known as Multiplier Boost Converter, in which the spike-type current among capacitors is eliminated through one resonant inductor, achieving some resonant-type current waveforms.
Notably, in a nonhuman primate study of HIV-1 envelope glycoprotein trimer antigen comparing DNA prime/protein boost regimens, in which all animals received protein antigen adjuvanted with Adjuplex, neutralizing antibody breadth and titers exceeded the levels achieved by previous vaccine regimens in primates (15).
A promising way to improve the quantity of antibodies against the conserved region of the stem seems to be a prime-boost regime, in which a DNA vaccine primes and a conventional vaccine boosts the immune response (21).
One of the more probable scenarios leading to the optimal immunization strategy of next-generation vaccines would be a prime-boost schedule in which DNA or live carrier vaccination are followed by boosts with a polyvalent subunit vaccine.
One promising approach towards the development of potential vaccine candidate in maintaining strong and durable immunity is the "prime-boost" strategy in which immune response is primed with a plasmid DNA and subsequently boosted with either a protein Ag or with a modified viral vector expressing the same Ag [15].
Many vaccines are enhanced by combining DNA with other vaccines in "prime-boost" regimens, in which the second vaccine is often a recombinant viral vector or purified protein subunit.
Simulating laser wakefield acceleration (LWFA) in a Lorentz boosted frame in which the plasma drifts towards the laser with vb can speed up the simulation by factors of γb2="(1−vb2/c2)−1.
Prime-boost protocols in which PspA5-DTPlow and PspA5-DT are combined can be tested and this also opens the possibility of inclusion of PspA5 in the DT vaccine given to adults.
This was the first report of successful induction of partial protection against a pathogen with a mucosal prime-boost regimen in which recombinant Lactobacillus strains were used as antigen-delivery vehicles [ 6].
