We demonstrate that incorporating functional association information can substantially boost correct identification of proteins in a shotgun proteomics experiment, across a range of sample conditions and mass spectrometers.
These modifications are detectable in a deep sequencing experiment, and if they are specific for miRNAs, incorporating them into a scoring system should further boost the identification of miRNAs.
Implementation of similar ideas in a GWAS showed boosting in identification of disease-associated genes [ 14].
Mall, R. et al. RGBM: regularized gradient boosting machines for identification of the transcriptional regulators of discrete glioma subtypes.
Sobel, M.E., (2012), "Does Marriage Boost Men's Wages?: Identification of Treatment Effects from Fixed Effects Regression Models for Longitudinal Data," Journal of the American Statistical Association, 107:5210729.
Still, we are convinced that the need for personalized medicine will boost the search and identification of single miRNAs and/or miRNA signatures characterizing specific patients and thus will help in guiding therapies.
The identification of new compounds that can boost progerin degradation will significantly improve recovery for children affected by this syndrome.
The use of boosted regression trees and hierarchical partitioning allowed accurate identification of the most influential environmental predictors and the responses of the species to them.
These boosted features facilitate figure-ground segmentation and the identification of targets in noise, diminishing the need for filtering by the parietal cortex.
Teamwork is an opportunity for mutual learning, it facilitates the identification of employees and the organization, boosts the quality of work and contributes to the achievement of the objectives of professionals and the organization [ 48– 50].
Further improvements in sequencing technology together with the identification of novel RP genes will undoubtedly boost the success rate of NGS-based diagnostic approaches in RP in near future.
