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"For longer-term protection to prevent future outbreaks one could envisage using the combination, the so-called prime / boost approach".
The pathology and cytokine expression data from guinea pigs support the protective potential of α-crystallin based prime boost approach.
In this study, we evaluated the protective efficacy of a heterologous prime boost approach targeting α-crystallin - a key latency-associated antigen against TB.
Compared to the DNA prime-rAd boost approach previously reported [21], the single-dose rAd strategy reported here has the advantage of a streamlined vaccination protocol.
We show that the prime boost approach based on α-crystallin provides a superior and extended protection against M. tuberculosis infection in guinea pigs.
We evaluated the protective efficacy of a heterologous prime boost approach based on recombinant BCG and DNA vaccines targeting α-crystallin, a prominent latency antigen.
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The most prominent amongst them is the heterologous prime-boost approach, which shows a great promise towards designing and development of a new efficacious tuberculosis vaccine.
The VSV replicates, unlike the chimpanzee adenovirus vector, stimulating an immune response that Geisbert argues is as good as the one achieved by the prime-boost approach NIAID has championed.
In this study, the mycobacterial antigen HSP65 was used to determine whether priming cattle with a plasmid DNA vaccine and subsequently boosting with the recombinant protein in adjuvant (heterologous prime-boost approach) would result in improved and more homogenous immune responses over immunising with plasmid DNA or protein in adjuvant alone.
We combine these features and use an online boosting approach to create the specific person classifier.
On the other hand, the boosting approach samples the instances in proportion to their weights.
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