Hence, the induction of PTEN SUMOylation by VSV may be considered as a means to boost a cellular response to virus replication.
IFN-γ and IL-2 ELISPOT analysis showed that PB VLPs did not induce an immune response nor did they boost an immune response to a DNA vaccine prime.
As several studies have indicated enhanced immune responses can be achieved by heterologous prime-boost inoculation regimens, we chose to investigate the immune response of p17/p24 alone and its ability to boost an immune response to a DNA vaccine pTHGagC that is known to prime an immune response of mice, which can be effectively boosted by Pr55Gag VLPs [ 30].
The use of heterologous platforms to initially prime and subsequently boost an immune response has been shown to be effective for eliciting antibody responses [42], [43], [44], [45], [46] but is especially attractive for augmenting T cell responses [47], [48], [49], [50].
Usually in cancer vaccination, epitopes from one organism are included in the genome or linked with some protein of another in the hope that the immunogenic properties of the latter will boost an immune response to the former.
Intriguingly, small molecules can now be developed to abrogate the Mtb-induced alteration of host cell-signaling in order to boost an effective response of the immune system.
Another approach to improving the discovery of genes specifically involved in the immune system would be to boost an immune response prior to cDNA sampling.
In this study we examined whether the ability of PPC to boost a T cell response is due to an effect on the proliferative or contraction phases, or both, of the primary response.
These findings suggest that, like melody, rhyme can boost a positive emotional response and the likeability of a spoken text.
Current immunotherapies are primarily aimed at harnessing both the innate and adaptive immune systems to initiate or boost a strong immune response to tumors and their antigens.
