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Finally, ontogenetic patterning of bones in response to mechanical loading is reviewed.This article is part of a Special Issue entitled "Muscle Bone Interactions".
Past research identified osteoblast as being recruited to bone surfaces to form new bones in response to loading [ 5].
In bone organ culture, changes in the concentration of Ca2+ and phosphate in the medium alter the release of previously incorporated Pb from fetal rat bones in response to parathyroid hormone (PTH).
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However, regional analyses showed differences in terms of strain-dependent distribution of newly formed bone in response to loading.
However, Colα1(I) 2.3-Cre Kif3a(fl/fl) mice did exhibit decreased formation of new bone in response to mechanical ulnar loading compared to control mice.
Both genotypes were less mechanoresponsive (in terms of volume and area of newly mineralized bone in response to loading) in adult compared to young mice (Fig. 3, effect of (f) age & loading p < 0.002).
We showed that with Sost deficiency the load-induced cortical resorption response, in terms of volumes and surface area of resorbed bone in response to loading, was similar to that of LC mice (Fig. 4).
It may be caused either by high tensile stresses or by osteolysis of the surrounding bone in response to the presence of particle debris.
Fundamentally, if we accept that hypertrophy of bone in response to increased loading is a desirable occurrence, then disuse is not a pathological process, but simply the corollary of adaptation to increased loads.
The mouse produced bone in response to mouse and rat dentin matrix but not to guinea pig dentin matrix.
It is well established that remodelling of bone in response to a load occurs via complex mechanotransduction mechanisms.
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