Nonetheless, in addition to congenital hydrocephalus, defects in other organs (such as the cardiovascular system, bones, and kidneys) were also found in these congenital mutant or genetically modified mouse models [21], [22], [23], which rather differs from p23-ST1 mice or NPH patients.
Variable dissemination of CD20+ lymphoblastoid cells was observed in lymph nodes and spleen, while bone marrow and kidneys were usually unaffected (Figure 1B).
Absolute cell numbers of spleen, bone marrow and kidneys were assessed by automatic cell counting either by Schaerfe CASY Cell Counter Schaerfe System GmbHH, Reutlingen, Germany) or by MACSQuant Analyzer (Miltenyi Biotec, Cologne, Germany).
Whereas common manifestations in joints, skin, mucous membranes, bone marrow and kidneys are usually rather easily identified, more subtle manifestations, such as neurological symptoms, may remain unrecognized or not judged to be related to SLE [ 1].
Sensitive compartments, such as the bone marrow, gut, and kidneys are protected from the toxic effect of the drug.
Therefore, calcium transport processes in the intestine, bone and kidney are tightly regulated to fine-tune the rate of absorption, storage and excretion.
The radioactivity from these compounds also accumulated in bone and kidney, was cleared rapidly from the blood, and was excreted in the urine.
There were no gross and microscopic pathological findings in the surviving hares, and organs collected aseptically (liver, spleen, lung, bone marrow and kidney) were free of F. tularensis based on culture and the mouse inoculation test.
To experimentally validate the predicted brain-specific and ovary-specific editing sites, two human tissue samples (brain) and ten human cell lines (from brain, ovary, colon, breast, bone, bone marrow, lymph, liver, and kidney) were used.
To investigate the effect of soy isoflavones on metastasis of established carcinomas, the metastatic foci in lung, bone, liver, heart, and kidney were analyzed.
