This pilot study investigated the biomechanical properties of prefabricated, vascularized bioartificial bone grafts, which may provide an alternative bone source for the restoration of segmental osseous defects.
Taken together, these studies suggest Nrf2 represents a key pathway in regulating bone metabolism, which may provide future therapeutic targets to treat osteoporosis.
These results suggest that the radiation-activated CHK1/MEPE pathway exacerbates the effects of microgravity on bone density loss, which may provide a novel targeting factor/pathway for a future countermeasure design that could contribute to reducing osteopenia in astronauts.
To consolidate the outcomes of research on IGF-1, we need to explore new bone-related factors, which may provide an insight towards precise skeletal growth assessment during puberty.
We also determined the effect of negative pressure on the mRNA expression of vascular endothelial growth factor (VEGF) and bone morphogenetic protein (BMP -2, which may provide more useful information for understanding the potential mechanism BMP -2ch negative pressure influences bone formation.
Furthermore, in this study, we have identified networks of genes involved in early and late bone formation, as well as genes associated with human arthritis, which may provide potential targets for modulating bone formation in arthritis.
Conclusions: The disruption Pb has on bone mass and bone homeostasis is principally explained by inhibition of the Wnt/β-catenin pathway, which may provide a molecular basis for novel therapeutic strategies to combat Pb-induced bone pathologies.
The objective of this review is to develop a molecular understanding of the mechanotransduction processes in tissue regeneration, which may provide new insights into bone physiology.
We investigated bone properties in postmenopausal women with bound feet, which may provide new information for developing countermeasures for prevention of fragility fractures.
In conclusion, we provide evidence for recent positive selection operating upon a crucial gene in skeletal development, which may provide new insight into the evolution of the skeletal system and bone development.
