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However, in addition to its direct beneficial effects, leptin has been reported to have indirect (central nervous system-mediated) antiosteogenic effects on bone, which may limit the efficacy of elevated serum leptin to prevent estrogen deficiency-associated bone loss.
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For open procedures, techniques exist for surgeons to limit bleeding, which may limit postop bruising.
Single area which may limit generalisability.
Moreover, autologous bone marrow derived MSCs are functionally abnormal in some disorders such as lupus [ 42, 43], rheumatoid arthritis [ 44] and systemic sclerosis [ 45], which may limit their clinical application.
Males were under-represented, which may limit generalizability.
However, tissue sampling was limited to a small number of sites in the eastern U.S. and 87Sr/86Sr analysis was conducted on bone, which may have integrated 87Sr/86Sr ratios from diet consumed over multiple periods of the year.
Drilling of bone is associated with an increase in temperature of the surrounding bone which may result in osteonecrosis.
The combinatorial effects of PRF on soft tissue healing and bone regeneration may limit its use in regenerative medicine applications in which calcification is not a desired outcome; however, our studies indicate that PRF contains a number of attributes ideally suited for its use as a scaffold for alveolar ridge augmentation and bone healing.
In the case of primary bone tumours, where remodelling of bone and the normal structural integrity of bone may limit the ability to detect disease regression, functional imaging is likely to play a particularly important role.
Taken together, these observations indicate that restoration of bone formation may limit growth progression in osteolytic bone metastasis.
For this reason there has been increasing interest in studying architectural parameters of bone, beyond bone density, which may affect bone strength.
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