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Animals treated with the mineralization membranes exhibited the highest bone volume within the defect as measured by micro-computed tomography and histology with no significant increase in inflammation.
Therefore, increased bone volume within the spongy bone compartment of the callus did not change the overall mechanical properties of the tissue.
The bone volume within the ROI of each group was then expressed as a percentage of the total defect volume of nonoperated calvarial bone (not shown).
The quantification of the new bone volume within the defect area was done using 55 sagittal μCT images (8 animals/group) with an image distance of 0.236 mm each.
Similar(56)
Reloading results in recovery of bone volume within 14 days, although osteoblast and osteoclast numbers remain below control values, suggesting decreased bone turnover.
Measuring the bone density in the remodelled bone, i.e. both the new bone-forming frontier as well as the more or less remodelled area underneath this front, the total bone volume fraction within the remodelled area was 35% (sd13) in the zoledronate treated grafts compared to 19% (sd 12) in the controls (p = 0.01).
The primary outcome measure was bone volume fraction within the defect (BV/TV), determined with high-resolution quantitative computed tomography (HR-QCT) after 5 weeks.
Our results demonstrated that while COX-2−/− female mice had normal bone geometry and trabecular microarchitecture at 4 months of age, the male knockout mice displayed reduced bone volume fraction within the distal femoral metaphysis.
In the ZOL group bone-to-screw contact and bone volume values within the defect tended to increase.
This quantity is defined as the ratio of the bone tissue volume within the volume of interest (VoI, specified in the insert in Figure 5) to the difference between the VoI and the volume of the implant material therein.
In contrast, trabecular bone volume of the axial bone (third lumbar vertebra) was unaffected by AIA.
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