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In our study, no significant differences in the enthesis area and adjacent subchondral bone volume were observed among the groups.
These results suggest that either high-Ca diet or exogenous PTH 1 34 treatment can increase adult mouse bone density, bone volume and bone formation, and synergistic effects in adult mouse bone density and bone volume were observed in the combined treatment group.
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An age-dependent decrease in trabecular bone volume was observed in both females and males, as expected (r = − 0.75 and r = − 0.63, p < 0.001, respectively).
No significant change in the bone turnover or bone volume was observed in the standard phosphate-binder therapy group.
An increase in bone volume was observed for siGNAS1, siPHD2, and siGNAS1-siPHD2 from Day 7 to Day 70.
An increase in the bone volume was observed with the loss of ASK1 based on three-dimensional microCT reconstructions of representative ectopic masses.
For example, in the proximal tibia, a significant decrease in trabecular bone volume is observed 2 weeks after ovariectomy compared to sham control with a plateau by 14 weeks after ovariectomy [ 35].
At Day 36, the maximal bone volume was observed for siPHD2-SFCS and was higher than Day 7. By Day 70, bone volume for siGNAS1-SFCS increased compared to Days 7 and 21, that for siPHD2-SFCS increased compared to Day 7, and that for siGNAS1-siPHD2-SFCS increased compared to Days 7 and 36.
In vivo osteogenesis was characterized by almost bridged defects with newly formed bone after 8 weeks in group I. Significantly (P < 0.01) greater bone volumes were observed with the pdHMSC/SS (group I) implants than with groups II, III or IV.
Survival time and tumor volume were observed.
The tumor volumes were observed.
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