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Results: The injection of EP4 agonist alone did not induce notable changes in body weight, macro-structures, or bone volume compared with the vehicle-treated group or the untouched control side.
Overall, therefore, Thra1 PV /+ mice have increased cortical and trabecular bone volume compared with WT, but their bone is less mineralized.
The region we measured as a periarticular site was composed of a small bone volume compared with the whole skeletal bone, including the cortical bone compartment.
At 18 months of age, PPARβ−/− mice exhibited lower cortical tissue volume and bone volume compared with PPARβ+/+ mice together with increased endocortical porosity.
Histomorphometric analysis of bone in the proximal tibia after 6 weeks showed both Pb and HFD to be associated with a significant decrease in trabecular bone volume compared with LFD mice and significantly interacted to lower BV/TV.
86, 87 Hypothalamus-specific NPY knockout mice show a significant decrease in body weight, a significant increase in food intake, and a two-fold increase in trabecular bone volume compared with wild-type animals.
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In addition, at the late time point only implants with the 200/800 pattern revealed a significantly higher bone volume compared to the rough controls.
In a small intervention study [ 22] treatment of osteoporotic subjects with silicon in the form of monomethyltrisilanol increased trabecular bone volume compared to non-treated controls.
Using healthy men and women, the authors confirmed that men have greater knee subchondral bone area, cartilage thickness, and cartilage volume compared with women, after adjustment for height and weight [ 20].
Results: BDL rats had decreased bone mass compared with SO rats as indicated by a 6% decrease in femoral and tibial bone mineral density (BMD), 18% reduction in femoral trabecular bone volume (bone volume/total volume [BV/TV]), 17% decrease in trabecular thickness, and 10% decrease in tibial cortical thickness.
Mice with CIA had a significant reduction in bone density and bone volume when compared with control animals, which was verified at necropsy (severe trabecular damage accompanied by cartilage destruction).
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