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In this previous study, we demonstrated a positive association between vastus medialis cross-sectional area and patella bone volume, but not cartilage volume.
In a community-based population of women, we recently showed that increased vastus medialis cross-sectional area was positively associated with patella bone volume, but not patella cartilage volume [ 12].
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The authors also showed that bisphosphonate treatment increased bone volume but did not decrease the number of osteoclasts at the site of bone metastasis compared to those who did not receive bisphosphonate [ 30].
Thus, the balance between osteoblastic and osteoclastic activity not only dictates healthy bone volume but also contributes to maintaining hematopoietic homeostasis.
In vivo, all implanted constructs gave rise to endochondral bone formation, whereas the bone volume was not affected by the length of priming time.
Also tibial bone volume was not different between wildtype and Per2Brdm1/Cry2−/− double mutant mice (Figure S4).
The change in bone volume does not completely match the change in BMD.
The histomorphometric analysis also revealed that when total bone volume was considered as both mineralised bone and osteoid, as established previously (Parfitt et al, 1987), the total bone volume did not significantly change (Supplementary Figure 3).
Another strength is the use of 3.3 mm diameter implants in a region, where the bone volume might often, but not always be available for larger diameter implants.
1,25(OH)2D3 therapy led to a significant increase in trabecular bone volume not only in comparison to vehicle-treated AIA (p < 0.01) but also compared to healthy animals (p < 0.01).
While bone volume fraction did not significantly differentiate human and great ape trabecular bone structure, human metatarsal heads generally show significantly more anisotropic trabecular bone architectures, especially in the dorsal regions compared to the corresponding areas of the great ape metatarsal heads.
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