Calcium sulfate is a well-studied, non-immunogenic, biocompatible bone void filler used in orthopaedic applications since the 19th century.
ALE made the B-247 and controls for surgeries, performed the osteoblast mineralization assays, assisted in the bone void and ridge augmentation surgeries, and assisted in publication of this manuscript.
While most of these strains are sensitive to colistin, the drug is not available in bone void fillers for local high-dose delivery.
geneX® is safe and an effective bone void filler when used in accordance with the Instructions For Use.
A total of 20 adults (16 male, 4 female, ≥ 18 years) suffering from post-traumatic or post-operative bone infection (osteomyelitis/osteitis) of the upper or lower extremities with potentially gentamicin-sensitive bacteria and with an indication for implantation of a bone void filler material were included in the investigation.
The main emphasis is placed on the progress of polyurethane applications in bone regeneration, including bone void fillers, shape memory scaffolds, and drug carrier.
In contrast, antibiotic-impregnated bone void fillers or cements can act as local anti‑infective drug release systems, which not only fill up the dead space after surgical debridement but also deliver high antibiotic concentrations at the site of potential infection, without increasing serum antibiotic levels.
The investigated new bone void filler composite can, overall, provide adequate protection against bacterial infection in all those challenging, at risk, patients with chronic osteomyelitis/osteitis during the first weeks after implantation and to support the bone healing process.
The development of particulate bone void fillers with added biological function to augment skeletal tissue formation will lead to improved efficacy in bone replacement surgery.
This investigation in adult patients with severe, chronic post-traumatic or post-operative bone infections and normal renal function demonstrated that these novel calcium sulfate-based bone void filler beads with gentamicin are a clinically useful local antibiotic delivery system and bone void filler/ bone substitute which can be used as an alternative to other anti-infective implants.
