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Therefore, we can assume that the bone uptake may be even lower once a full human dosimetry study has been carried out.
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"In other countries, uptake may be harder because doctors think of it as just a dietary intervention".
It seems likely, however, that where enhanced pay is not offered, or where employers are unable to accommodate discontinuous leave requests, uptake may be low.
This uptake may be symmetrical or asymmetrical.
We observed bone uptake that may be consistent with Her-2 expression in haematopoietic cells [15].
This bone uptake may prevent the detection of bone metastases, and hampers accurate estimation of the radiation dose to the bone marrow in dose planning for radioimmunotherapy.
The diffuse increase in FDG uptake in the bone marrow may be caused by the presence of malignancy or haematopoietic disease, but also may be due to an inflammatory reaction, stimulation by some types of malignancy, as a result of recent chemotheraphy, or to the administration of haematopoietic growth factors.
Consequently, standardised tracer uptake close to bone may be underestimated [12], which could in particular apply to the retrosternal parts of the heart.
Defects in uptake in the bone may be seen with a number of malignancies, typically lung cancer and breast cancer and occasionally in myeloma.
There is broad agreement that due to the high concentration of BPs in bone, bone metastases are the tumours most likely to be directly exposed to significant levels of the drugs for prolonged periods of time, and tumour cells residing in bone may be directly affected through uptake of BPs released during normal bone turnover.
Bone QUS may be one such substitute.
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