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In the present study we assessed serum markers of bone formation and resorption, which likely confirms reduced bone turnover over time.
The baseline-adjusted AUC (henceforth referred to as AUC for weeks 0 12 and 0 24 was calculated for all bone-turnover markers to evaluate accumulated changes in bone turnover over time, rather than at discrete time points [ 19].
The baseline-adjusted area under the curve (AUC) for weeks 0 12 and 0 24 was calculated to evaluate changes in bone turnover over time, rather than at discrete time points.
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The final result is a profound suppression of bone turnover and, with time, a reduction or cessation of bone remodeling.
Overall, ocean oxygenation and/or ecological restructuring of ecosystems may have driven biologic turnover over time.
In fact, if one expressed ATP turnover over time there may be a scenario in which forced hypometabolism rapidly decreases ATP turnover, eventually leading to cell death.
This was most likely due to slowing growth rates of the animals (resulting in slower matrix turnover) over time.
The mice showed increased bone turnover, and over-expressed TRAP in the same locations as the endogenous genes [10].
Ovariectomy significantly decreased bone mass at the lumbar spine, proximal femur, femoral neck and radius, and increased bone turnover in a time-dependent manner.
In RA a variety of factors, such as the impact of systemic inflammation, corticosteroid use, and menopause, may influence bone resorption, bone turnover and skeletal status over time.
Secondary objectives included comparison of bone turnover markers over 12 months.
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