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In the other hand, the material properties of bone tissue should be assumed from the beginning.
It is well known that the scaffolds used for bone tissue should be biocompatible, cell proliferative, and exclusive from immune response [21].
Possible separate effects of tryptophan degradation products on bone tissue should be investigated further in experimental studies.
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In other words, the surrounding soft tissue should be in the best possible condition, a key factor in the successful bone reconstruction.
So in the substantial studies ET concentrations at the site of osteoporotic bone tissue should also be evaluated by biopsies.
When a malignant tumor such as thyroid cancer is suspected, the presence of any other tumors in the brain, bones or soft tissues should be considered as potential metastases, unless other pathologies are ruled out.
As a bone tissue engineering, the ideal bone tissue scaffolds should be osteoconductive, osteoinductive, and osteogenic.
Ideally, the scaffold for bone tissue engineering should be porous with appropriate pore size and high interconnectivity to encourage cell penetration, tissue ingrowth and rapid vascular invasion, as well as nutrients delivery.
Since type I collagen is an integral component of bone tissues, it should be no surprise that abnormalities affecting this protein would impact bone material quality.
During the late stages of regeneration and as part of the remodelling of newly formed bone tissue when cancellous bone should be populated with cells of bone marrow, the BMP level is decreased, whereas SDF-1 is again increased, which provides a homing of hematopoietic stem cells (HSC).
An optimal scaffold for bone tissue engineering applications should be biocompatible and act as a 3D template for in vitro and in vivo bone growth; in addition, its degradation products should be non-toxic and easily excreted by the body.
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