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Regeneration of damaged bone tissue has been a major goal for both clinicians and researchers worldwide.
A tissue-vectored bisphosphonate fullerene, C60(OH)16AMBP [4,4-bisphosphono-2- polyhydroxyl-1,2-dihydro-1,2-methanofullerene[60]-61-carboxamido)butyric acid], designed to target bone tissue has been synthesized and evaluated in vitro.
This cluster-based method for the localization of bone tissue has been tested on head/neck imaging but should be straightforward to apply to other non-moving areas.
The elastic modulus of the trabecular bone tissue has been suggested to be close to that of the cortical bone tissue [ 8].
The importance of physical factors in the development and maintenance of bone tissue has been recognized for many years (Harada and Rodan 2003) and it has been convincingly shown that bone cells are sensitive to physical stimuli.
Background While the importance of physical factors in the maintenance and regeneration of bone tissue has been recognized for many years and the mechano-sensitivity of bone cells is well established, there is increasing evidence that body fat constitutes an independent risk factor for complications in bone fracture healing and aseptic loosening of implants.
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Various methods for manufacturing scaffolds to replace bone tissue have been developed.
Ex vivo and in vivo therapeutic procedures for gene delivery to local bone tissue have been reported {reviewed in [2]}: i) the gene is introduced into cultured cells, which are then implanted into the patient (ex vivo transfer) [3] [6], or ii) the gene is transferred directly into the target sites (in vivo transfer) [7] [11].
The mechanical properties of trabecular bone tissue have been extensively investigated in the past [ 1– 9].
At the turn of the millennium, a new concept of calcium orthophosphate bioceramics, which is able to regenerate bone tissues, has been developed.
Some crucial physical and biological mechanisms underlying the sophisticated damage, remodeling and healing process of bone tissues have been incorporated in the model.
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