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In 6 patients the potency of bone tissue engineering to reconstruct jaw defects was tested.
Several studies have applied SIS in bone tissue engineering to enhance bone regeneration in animal models.
Bone morphogenetic protein-2 (BMP-2) releasing scaffolds are routinely used in bone tissue engineering to accelerate regeneration.
Hence, it may be reasonable to combine adMSC spheroids of varying differentiation stages in scaffolds for bone tissue engineering to promote both vascularization and bone formation.
Following advances in basic science, many new insights focus on bone tissue engineering to optimize therapies and facilitate prognosis of ONFH.
Moreover, the recent reports related to the ability of AuNPs to enhance stem cell differentiation for bone tissue engineering, to enhance the mechanical and adhesive properties of scaffolds and surface topography to guide cell behaviors are addressed.
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To our knowledge, this is the first use of multiphoton microscopy in bone tissue-engineering to investigate angiogenesis in scaffolds in vivo.
Additionally, sericin can be used for bone tissue engineering owing to its ability to induce nucleation of bone-like hydroxyapatite.
Composites of collagen type I and calcium phosphates are widely used in bone tissue engineering due to the similarity to natural bone and capacity of enhancing osteoblast differentiation and accelerating osteogenesis [ 143, 148, 149].
One of the future challenges in bone tissue engineering is to design and to manufacture biodegradable scaffolds with a homogeneous growth rate over their entire volume, using pore size gradients or specific distributions of embedded growth factors.
Hydroxyapatite (HA)/polysaccharide composites have been widely used in bone tissue engineering due to their chemical similarity to natural bone.
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