Histological examination of the tibias revealed discontinuous eroded bone trabeculae with widened bone marrow spaces in OVX rats accompanied by a significant decrease in both cortical and trabecular bone thickness compared to Sham rats.
After adjusting for covariates, Canadian adolescent and young adult South and Southeast Asian males had greater cortical bone density and thickness compared with Caucasian males.
Since male Lrp5 −/− mice show no osteogenic response to loading in the bone cortex, and an absence of dose-responsiveness for trabecular thickness, compared with their dose-responsive WT controls, this could be ascribed to their Lrp5 status.
The latter may result from a relatively greater increase in bone diameter compared with cortical thickness (Stroup et al 2008).
We have observed a decrease in the thickness of the subchondral bone plate compared with those healthy ones.
In the loaded tibiae, loading induced increases in trabecular and cortical bone volume compared with contra-lateral controls primarily through increased trabecular thickness and periosteal expansion, respectively, independently of risedronate treatment.
Treatment with Zol dramatically improved bone volume, trabecular number and trabecular thickness compared to the Sham and MM groups.
Results: BDL rats had decreased bone mass compared with SO rats as indicated by a 6% decrease in femoral and tibial bone mineral density (BMD), 18% reduction in femoral trabecular bone volume (bone volume/total volume [BV/TV]), 17% decrease in trabecular thickness, and 10% decrease in tibial cortical thickness.
In the distal femur of adult mice, SRT2104 significantly improved trabecular bone volume, trabecular connectivity, and trabecular bone mineral density compared with control SD-fed animals (Fig. 1H J); however, no effect in cortical thickness was observed (data not shown).
Regarding cortical bone, the calorie-restricted groups had reduced values of bone volume, mean polar moment of inertia, and cortical thickness compared to the AL groups (P <.05).
