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E2 completely prevented OVX-induced bone loss, suppressed bone turnover, and induced uterine hypertrophy and hypercholesterolemia. 16α-OHE1 asted an an E2 agonist on bone, suppressing bone formation and resorption.
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Zinc supplementation has been reported to inhibit bone loss in an adjuvant-induced rheumatoid arthritis rat model, promoting bone formation and suppressing bone resorption [ 17].
Thus, SRT2104 affects both features of age-related osteoporosis by increasing bone formation and suppressing bone resorption in a SIRT1-dependent manner.
This was expected as it has been established that treatment with bisphosphonates induces higher trabecular bone mass by suppressing bone resorption especially during the growing period [41].
It has been reported that anti-inflammatory and anti-oxidant agents have the potential to treat osteoporosis by increasing bone formation and/or suppressing bone resorption.
Previous studies have shown that anti-inflammatory and anti-oxidant agents have the potential to treat osteoporosis by increasing bone formation and/or suppressing bone resorption [ 15, 16].
Anaemia was the second most common haematologic toxicity occurring in our study, and was expected because both cisplatin and eribulin mesylate are bone marrow suppressing cytotoxic agents.
An acid-condensation product of I3C, 3,3′-diindolymethane (DIM), prevents ovariectomized-induced bone loss by suppressing osteoclastic bone resorption [19].
These data demonstrate that eldecalcitol was capable of increasing bone mass not only by suppressing bone resorption, but also by stimulating bone formation.
In severe combined immunodeficient-rab mice with contralaterally implanted pieces of bones, BTK knockdown in myeloma cells promoted their proliferation and growth in the primary bone but suppressed metastasis to the contralateral bone.
Dysregulated inflammation leads to increased bone resorption and suppressed bone formation.
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