To quantify differences in bone structure in the proximal tibia of patients with mild, definite and advanced osteoarthritis (OA) compared to healthy reference tibiae.
Variables of cancellous bone structure in the hypoparathyroid subjects, as assessed by microcomputed tomography, were highly correlated with those assessed by conventional histomorphometry.
The fracture behavior of human bone is an interesting field of research for medical scientists, which are interested in predicting the fracture risk, but also for engineers, which are interested in mimicking bone structure in the design of new materials.
Dairy foods and changes in body mass can affect bone architecture; therefore, our objective was to examine the effect of dairy proteins on bone structure in the tibia of dietary-induced obese rats.
Radiographically, the bone structure in the lesional areas was related to age in all grades of cherubism: new bone formation in radiolucent areas (age, >20 years), normal bone structure with multilocular sketches (age, 32 to 39 years), and completely normal bone structure (age, >41 years), also found in 7 of 7 carriers of cherubism (age, >32 years).
The micro-CT results are confirmed by the histological results (Figure 5 and 6), showing normal trabecular bone structure in the untreated control mice (Figure 5A, 5B and 6A) but evidence of both lytic and sclerotic effects in the untreated tumour-bearing bones (Figure 5C, 5D and 6B).
This finding was supported by previous studies which reported that ovariectomized rats showed significant deteriorations in the bone structure in the first three months [ 80].
Recently, IL-6 blockade was shown to potently inhibit osteoclast formation and bone erosion in hTNFtg mice without suppressing joint inflammation, suggesting that IL-6 blockade may have beneficial effects on bone structure in the treatment for arthritis [ 21].
