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Repetitive mechanical loading which exceeds the bone strength is the cause of this complication.
Reduced bone strength is the main characteristic of osteoporosis, resulting in an increased risk of fractures [ 1].
A limitation of the available data on racial variation in BMD, fracture and other parameters related to bone strength is the heterogeneity of individuals within even a single racial category.
In the absence of fragility fracture, bone mineral density (BMD), a proxy measure that accounts for up to 70% of bone strength, is the clinical tool used to diagnose osteoporosis according to the classification of the WHO.
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But every time a new genetic study about boosting muscle quality or blood supply or bone strength is published, the calls start up again.
The bone strength is determined by the bone mass and the intrinsic properties of the bone material [ 44, 45].
The resultant overall increase in bone strength is consistent with the lower rates of non-vertebral fractures in Asians versus whites.
Overall bone strength is difficult to measure in the clinical setting.
Therefore, the identification of alternative ways to increase bone formation and maintain the bone strength is considered vital, especially for menopausal women.
The importance of collagen properties in determining bone strength is emphasized by several publications in the literature reporting altered collagen properties associated with fragile bone, in both animals and humans [6,17,18,22,34,37 39,45 51].
In metastatic prostate cancer, bone structure is disordered and bone strength is suboptimal because prostate cancer cells create an imbalance in the normal osteoprotegerin to RANKL ratio essential for the maintenance of normal bone remodeling.
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