Ovariectomized rats given Wyeth 14643, maintained whole body BMD at sham levels, while rats on pioglitazone had lower whole body and femoral BMD, impaired bone quality and less mechanical strength compared to sham and ovariectomized controls.
The mechanical properties of today's available porous scaffolds are analyzed in detail, revealing insufficient elastic stiffness and compressive strength compared to human bone.
The mechanical properties of today׳s available porous scaffolds are analyzed in detail, revealing insufficient elastic stiffness and compressive strength compared to human bone.
We found that the autoclaved autogenous bone graft has the highest mechanical strength compared to the control group, followed by the irradiation group and pasteurization group.
SrRan increased pull-out strength compared to controls (+34%), with a significant improvement of bone microarchitecture around the implant, a more plate-shape structure and an increase in bone-to-implant contact (+19%).
Histomorphometricaly and in microcomputed tomography, trabecular bone showed increased bone volume (+48%), trabecular number (+21%) and bone formation rate, with reduced trabecular separation what improves connectivity and bone strength compared with placebo.
Hildebrand et al. found that a combination of BMD and trabecular structure measures may explain 94% of trabecular bone strength compared with 64% if only BMD measures are used [ 22].
Studies employing these technologies illustrate that the Chinese skeleton compensates for smaller bone size by advantages in both cortical and trabecular bone compartments that confer greater bone strength as compared to Caucasians.
Therefore, adolescent swimmers present similar bone strength values when compared to normo-active controls, and lower values when compared to weight-bearing athletes.
In recent years, a new generation of biodegradable metallic materials, magnesium alloys, has been called a revolutionary material for biomedical applications (i.e. in orthopedics applications as a bone-implant material), thanks to the reasonable strength (similar to bone tissue, compared to available metallic alloys) and high biocompatibility of magnesium and its alloys.
