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In our model, resorption occurred at pre-existing cavities within the bone, starting at the periphery around the pressurized area.
The VOI included the subchondral trabecular bone starting below the subchondral plate, and extending distally towards the growth plate, excluding both the cortical bone and growth plate interface.
Trabecular bone volume fraction (BV/TV), the ratio of the volume of bone present (BV) to the volume of the cancellous space (TV), was calculated for 1 mm of the bone, starting 0.2 mm from the growth plate.
The cortical volume of interest included subchondral bone starting at the distal boundary of the femur, extending up to the distal boundary of the growth plate, excluding trabecular bone.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com