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An analysis of the first appearance of skeletal metastasis in breast cancer patients revealed that patients with a solitary metastasis to bone (solitary bone lesion) had a better prognosis than those with multiple skeletal metastases (multiple bone lesions) [ 14].
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The difference in survival between patients with solitary bone metastases, multiple bone metastases, and additional visceral metastases was statistically significant (p < 0.001).
Four out of these five patients had locally confined PCa and were scheduled for RP while one patient presented with a solitary bone metastasis on the bone scan.
Stratified sub-analysis was conducted on groups of individuals with a solitary bone lesion or multiple bone lesions at their initial presentation of skeletal metastasis.
Relative contraindications for the use of radioisotopes include a solitary bone metastasis, pure osteolytic bone lesions, extensive soft-tissue metastases, current or expected pancytopenia from prior therapy, hemibody irradiation within the previous 8 weeks, acute kidney injury or chronic renal insufficiency, or disseminated intravascular coagulation.
27 patients had a solitary bone metastasis, 20 patients multiple bone metastases and 54 patients had concomitant visceral metastases.
The 5-year OS rate after resection of solitary bone lesions in other series was 40%[35]and54%54%, respectively [87], although numbers were very small.
Osteoma, small, often solitary bone tumour found mainly on bones of the skull.
26.7% had solitary bone metastases, 19.8% had multiple bone metastases and 53.5% had concomitant visceral metastases at the time of presentation.
The Kaplan-Meier curves for patients with or without pain are presented in figure 5. Patients with a solitary bone lesion and those with multiple bone lesions were analyzed separately.
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