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In addition, effects on bone scan were assessed by an independent reader, and pain and narcotic use were prospectively assessed using an interactive voice recording system and a diary.
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A bone scan was assessed at baseline and followed in those with bone disease at baseline or in any patient with new bone symptoms.
Baseline bone scans were assessed for the number of distinct lesions.
Abnormalities observed on bone scans were assessed using the same method every 6 weeks.
Isotope (99mTc) bone scans were assessed prior to treatment and graded from 1 4 according to severity using the method described by Soloway et al (1988).
Scans were assessed for presence and size of bone erosions and osteophytes in overall 530 2D slices.
Women were injected with 600 MBq 99mTc-MDP, and diagnostic bone scan images were assessed at 3.5 h.
Investigations (chest X-ray, abdomen ultrasound and bone scan) were performed to exclude distant metastasis and blood tests were performed to assess bone marrow, renal and hepatic function within 2 weeks of inclusion in the study.
MRI or bone scan were allowed when indicated.
Brain CT and bone scan were reserved to symptomatic patients.
Occasionally a nuclear medicine bone scan is used to assess the degree of loosening within the joint.
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