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The bone resorptive changes were not accompanied by any significant changes in the biomechanical parameters.
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The increased resorptive changes in bone morphometry may also be a general catabolic effect from the increased circulating levels of inflammatory TNF-alpha and IL-1beta, cytokines known to produce bone catabolism if elevated systemically [ 111].
Short-term and extended high-fat diet induced obesity caused significant bone loss in male C57BL/6J mice mainly because of resorptive changes in trabecular architecture.
The same inflammatory factors enhanced bone resorptive osteoclastic activity.
Both compounds reduced osteoclast formation and bone resorptive activity of osteoclasts in a dose-dependent manner.
Here we report that bone cells possess primary cilia that project from the cell surface and deflect during fluid flow and that these primary cilia are required for osteogenic and bone resorptive responses to dynamic fluid flow.
When the characteristic bone resorptive fields of the H. sapiens face first appeared is difficult to ascertain given the present dearth of juvenile faces in the Lower-Middle Pleistocene record outside Sima de los Huesos.
The radiographs were analyzed for any visual changes in osteotomy fragments, resorptive changes in osteotomy fragments, callus formation, and union of the osteotomy segments.
Endothelial growth factors [20], osteoclast precursors like osteocalcin, prostaglandins [21], bone resorptive factors like RANKL [22], leukotrienes [23], and macrophage colony-stimulating factors have been tested.
In addition, Bim in osteoclasts stimulates not only the apoptosis, but also the bone resorptive activity.
The data suggest that ZAS3 is important in multiple aspects of osteoclast formation and activity, including differentiation, survival and bone resorptive functions.
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