Sentence examples for bone resorption in a from inspiring English sources
We report the incidence of proximal tibial bone resorption in a large consecutive series of patients undergoing total knee arthroplasty, with a modern total knee design.
Moreover, in osteoclast precursors, Notch-RBP-J signaling is activated by TNF and in turn inhibits osteoclastogenesis and attenuates TNF-mediated inflammatory bone resorption in a feedback manner (Zhao et al., 2012).
Both IL-1 and TNF are inflammatory cytokines mediating bone resorption in a variety of diseases affecting bone.
HBO reduced the ability of precursors to form osteoclasts and reduced bone resorption in a treatment-dependent manner.
Thus, SRT2104 affects both features of age-related osteoporosis by increasing bone formation and suppressing bone resorption in a SIRT1-dependent manner.
In addition, IL-10 has been demonstrated to inhibit osteoclast differentiation in vitro [ 12] and to suppress infection-induced bone resorption in a murine model of periodontitis [ 13].
Conversely, VEGF-C is expressed in osteoclasts, where it enhances bone resorption in an autocrine manner via VEGF-R3 [38].
Bone labeling (index of bone osteogenesis) is present mainly at the periosteal surface, in particular in the sharp-edge-shaped sections in all groups; moreover, again in particular in sharp-edge-shaped sections, the endosteal surface shows an irregular outline (index of bone resorption) in all animals fed a calcium-deprived diet.
It therefore remains to be demonstrated that TNFα or IL-1, alone or in combination, can stimulate bone resorption in vivo in a manner that is truly independent of RANKL.
Consistent with the notion that it plays an important role in the pathogenesis of myeloma-associated osteolysis in vivo, there is now convincing evidence, in RANK knockout mice, that MIP-1α also stimulates osteoclast differentiation and bone resorption in vivo in a RANKL/RANK-dependent manner when it is expressed adjacent to bone surfaces [ 22].
