Osteoclast-dependant bone resorption could therefore enhance migration of mesenchymal stem cells to the bone plate region, which could be a key event in the cartilage repair properties of chitosan that is indirectly related to neutrophil recruitment.
Bone resorption could also be detected using bovine bone slices and subsequent toluidine staining.
No bone resorption could be observed at the anterior aspect of the ramus.
If bone resorption could be avoided during revascularization and formation of new bone, structural failure and collapse could possibly also be avoided.
Altogether, these data strengthen the notion that therapeutic interventions that effectively inhibit bone resorption could potentially be used as DMOADs.
In this study, we examined whether two weeks of in vivo tibial loading could enhance bone formation and reduce bone resorption in young and adult female Sost KO and LC mice.
Multiple myeloma (MM) expands almost exclusively in the bone marrow and generates devastating bone lesions, in which bone formation is impaired and osteoclastic bone resorption is enhanced.
VEGF-A levels are elevated in arthritis and thus osteoclastic bone resorption is enhanced.
Insulin-like growth factor-I also regulates bone resorption by enhancing osteoclast activity [ 24, 31, 44].
Preventing osteoclast bone resorption or enhancing osteogenesis through anabolic agents are being explored.
