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One explanation for the lack of bone resorption could be attributed to the failure of the multinucleated cells generated in response to IL-32 to express F-actin ring which ultimately is required for anchorage of the cells prior to bone resorption.
No bone resorption could be observed at the anterior aspect of the ramus.
If bone resorption could be avoided during revascularization and formation of new bone, structural failure and collapse could possibly also be avoided.
Early bone resorption could be associated with the high levels of PGE2, which is a known potent inflammatory agent and is paramount in recruiting osteoclasts in combination with IL-6 [ 18, 45, 46].
Since inflammation and bone resorption could be considerably dissociated as mentioned above, and many factors besides RANKL and M-CSF are thought to affect osteoclastogenesis [ 18], the effect of DHMEQ on in vivo osteoclastogenesis needed further investigation.
A detailed investigation of the effect of 1,25(OH 2D3 on bone turnover is necessary because the direct effects of 1,25(OH 2D3 on bone include the expression of RANKL which may result in increased bone resorption [ 35], whereas bone resorption could be suppressed indirectly by inhibition of inflammation [ 20].
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By sectioning the bone samples in midlength and perpendicular to the original drill hole the stage and ratio of new bone formation versus material resorption could be optimally visualized and calculated at its most remote location.
As no resorption could be identified in the preserved areas of these specimens, bone deposition was a key mechanism consistent with the anteriorly directed growth of the maxilla.
Bone resorption could also be detected using bovine bone slices and subsequent toluidine staining.
Altogether, these data strengthen the notion that therapeutic interventions that effectively inhibit bone resorption could potentially be used as DMOADs.
Inhibition of cathepsin K may therefore prevent bone resorption, as could be demonstrated in bone metastasis from breast cancer [ 16].
More suggestions(16)
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