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This imbalance stems from increased bone resorption compared with formation.
Risedronate treatment significantly reduced markers of cartilage degradation (Fig. 5) and bone resorption compared with placebo.
66cl4beta3 tumor growth in the tibia, however, increased osteoclast recruitment and bone resorption compared with 66cl4 tumors.
At post mortem these patients show diffuse replacement of marrow with plasma cells but have less severe bone resorption compared with lytic deposits.
The importance of OPN in mediating osteoclast function is evident as Opn knockout mice display minimal bone resorption compared with wild-type, an observation accompanied by decreased osteoclast association at the bone surface.
However, for the 2 mg dose, by 3 months (just prior to the next injection), there was a persistent and significant reduction in these markers of bone resorption compared with placebo of about 40% (p < 0.003).
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In total, the OR for presence of CVD among HF patients with SHPT or excess bone resorption compared to those with both parameters in the normal range was 7.54 (Table 6).
The OR for the presence of CVD is 2.68 times higher among subjects with SHPT and 2.58 times higher among patients with high bone resorption compared to patients without such a condition.
We observed 20% and 51% increases in BLLs among pre-and postmenopausal women, respectively, who were in the highest tertiles of bone formation and resorption compared with those in the lowest tertiles.
Orthodontic treatments in adults carry higher risks, such as gingival recession, alveolar bone resorption, and root resorption, compared with those in children [22, 23].
Exemestane was associated with a reduction in bone resorption markers compared with letrozole.
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