These findings suggest that there is an uncoupling of bone turnover following hip replacement surgery which is characterized by significant reductions in bone formation without compensatory decreases in bone resorption, potentially leading to bone loss.
We report a case of a woman presenting with severely injured lower limb and bone loss, which was managed using a custom-made endoprosthetic replacement for successful functional outcome.
Recent advances in bone biology have led to a more detailed understanding of bone remodeling which is a process that leads to resorption of old bone and replacement by formation of new bone.
Also, in children, if the main focus is fairly well excised, the adjacent bone which is mildly infected will frequently heal, and dead bone which is not sequestrated will be absorbed and replaced by living bone through creeping replacement.
Elastomeric composites are superior to the more commonly used thermoplastic-matrix composites, owing to the well-defined elastic properties of elastomers which are ideal for the replacement of collagen, a key elastic protein within the bone tissue.
The version of the device rejected by the F.D.A. was developed by DePuy for use in a hip replacement procedure called resurfacing, which is a bone-sparing alternative to standard surgery.
The version of the ASR rejected by the agency was developed by DePuy for use in a hip replacement procedure called resurfacing, which is a bone-sparing alternative to standard surgery.
The most advanced tissue-targeted antibody-based product the bone-targeted enzyme replacement-Fc fusion, asfotase alpha (Strensiq®), which was approved by the US FDA for treatment of hypophosphatasia (Hofman et al., 2016).
The series of Titanium bone replacement are very rare.
