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One of the best known processes of bone regulation is OPG/RANKL/RANK that regulates directly the action of osteoblasts and osteoclasts [ 7], and changes in the production of osteoprotegerin (OPG) and/or RANKL produces misbalances in bone remodelling which can lead to a major formation or resorption depending on the final balance between both proteins.
Based on the current available data, we conclude that it is not possible to determine whether SSRIs may negatively influence bone regulation or are innocent bystanders.
► APC plays an important role in bone regulation via the Wnt signaling pathway.
They may also yield new information about mechanisms of bone regulation.
Fetuins A and B, spp24 and latexin are reported to be involved in bone regulation and calcification [ 57, 61, 62].
Further, a number of genes specifically involved in bone regulation including other members of the Wnt pathway were also dysregulated.
Similar(47)
Many of the defeats, for example on the beef-on-the-bone regulations or the arrangements for the referendums in Scotland, Wales and London, concerned matters on which any second chamber would probably have wished the government to rethink.Nevertheless, the votes of hereditary peers have been needed to secure all but one of the government's defeats.
Regardless of how these evolving stories ultimately turn out, what they clearly illustrate is that bone mass regulation is also dependent on other organ systems besides the classical parathyroid-kidney-gut level of regulation that controls calcium and phosphate homeostasis.
Vitamin D receptor (VDR) gene plays an important role in bone mass regulation.
Wnt signaling through low-density lipoprotein receptor-related protein 5 (LRP5) is an important determinant of bone mass regulation.
Canonical Wnt/β-catenin signalling mediated by Lrp5 and Lrp6 plays a central role in mammalian bone density regulation [12].
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