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These results show that the biodegradable polymer/bioceramic composite scaffolds fabricated by the novel GF/PL method enhance bone regeneration compared with those fabricated by the conventional SC/PL method.
Examining wound healing in mice with the same gain of function mutation in LRP5, Kim and colleagues showed that at the injury site osteoprogenitor cells maintained their proliferative state and have delayed osteoblastic differentiation resulting in an 84% reduction in injury-induced bone regeneration compared with controls [56].
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Silkworm-cocoon-derived silk membranes showed comparable ability of bone regeneration compared to collagen and Gore-Tex® membrane [25].
We found that 3.6 × 106 or 1.8 × 107 H1/fBMpolyhedraenhancedanced bone regeneration compared to the rhBMP-2 group.
The silk fibroin film produced by the casting method resulted in greater bone regeneration compared to uncovered controls [3, 4].
The silkworm cocoon membrane produced by simple separation also showed greater amounts of bone regeneration compared to the ePTFE membrane [5].
Microcomputed tomography and histologic analysis showed that rhBMP2-containing d-BCPs significantly enhanced cranial bone regeneration compared to non-rhBMP2-containing non-rhBMP2-containing non-rhBMP2-containing
Surprisingly, unlike gelatin, collagen sponges incorporated with PRP have more variable results in the literature, ranging from the addition of PRP enhancing to PRP having no effect on bone regeneration compared to controls.
Our in vivo study confirmed the rhBMP2/d-BCP effects on bone regeneration; rhBMP2/d-BCP implants induced greater bone regeneration, compared to d-BCP alone, in the critical-sized calvarial defects in mice.
Regarding in vivo studies, so far, few studies have been performed on PRP for osteochondral regeneration compared with the extensive work on bone and other tissue healing [ 11- 13].
1) The CNF/HAP has a similar bone regeneration ability compared with the collagen membrane.
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