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The evaluation of bone quality should be performed in two species, such as the ovariectomised female rat model and larger animals (ewe, sow, primate etc).. Phase I studies are designed to enable determinations of pharmacokinetic profiles and bone diffusion and to offer indications of the putative clinical relevance of the dosages.
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The quality should be outstanding.
Quality should be a right for everyone.
The overall quality should be excellent".
The current evaluation approach based on bone mineral density (BMD) measurements lacks sensitivity, and it has become clear that as well as bone mass, bone quality should also be evaluated.
As available clinical radiographic techniques are limited in their measure of bone "quality", it should be of great interest to develop and validate testing techniques that allow the mechanical investigation of tissue and matrix properties in the clinic.
If it is associated with poor bone quality ORIF also should be recommended in combination with bone grafts especially for transverse B1 fractures.
Therefore, the in vivo behavior of these compounds (e.g., resorption rate and quality in bone ingrowth) should be taken into account as well.
Osteoporosis decreases the quality of internal fixation; hence patients with decreased bone stock should be considered for other alternative procedures.
For the assessment of quality of bone, tooth eruption should be evaluated as well as periodontal status of teeth adjacent to and in the former cleft area, success of orthodontic movement of teeth into the former cleft area and osseointegration of dental implants.
A bone graft should be used to fill the gap.
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