Reattachment and healing of tendon to bone poses a persistent clinical challenge and often results in poor outcomes, in part because the mechanisms that imbue the uninjured tendon-to-bone attachment with toughness are not known.
The traditional surgical methods with alveolar bone augmentation pose limitations on improving volumetric stability and implant stability.
In these and other diseases of the bones, infections pose serious problems.
As a result, cancer treatment-induced bone loss poses a significant threat to bone health in premenopausal women with breast cancer.
Spine interbody fusion cages of PEEK material have already been used clinically; however, poor bone compatibility poses an obstacle to the bonding of the implant and bone around it.
Bone curvature poses a paradox in terms of the mechanical function of limb bones, for many believe the curvature in these bones increases bending stress, potentially reducing the bone's load carrying capacity (i.e., its mechanical strength).
Total shoulder arthroplasty for end-stage glenohumeral arthritis with severe glenoid bone loss poses a unique challenge for shoulder surgeons.
The microenvironment in the bone metastases poses a considerable challenge for the infiltrating CAR T cells (see Fig. 2).
With this high level of demand, the repair of these bone defects poses a great challenge to the field of orthopaedic surgery.
Sex hormones interfere with bone metabolism, posing postmenopausal women at a much higher risk of hip fracture than men; most antihypertensive drugs appear to be beneficial for bone health in both sexes, however, risk differences are not eliminated.
Buruli ulcer (BU), caused by the environmental organism Mycobacterium ulcerans and characterized by necrotizing skin and bone lesions, poses important public health issues as the third most common mycobacterial infection in humans [ 1].
