Sentence examples for bone phenotype observed in from inspiring English sources

In addition, we cannot exclude that the reduced osteoclast formation in vitro and improved bone phenotype observed in critically ill rabbits treated with rapamycin is due to the immunosuppressive effects of rapamycin rather than its autophagy-inducing properties.

However, the normal bone phenotype observed in 34-week old Lef1+/− female mice favors the hypothesis that androgen signaling, much like aging in females, overrides the skeletal sensitivity to Lef1 haploinsufficiency by restraining bone turnover.

These findings strongly suggest that the bone phenotype of the Cry2-deficient female animals is based on lowered osteoclast activity and hence is mechanistically different from the bone phenotype observed in Per2Brdm1 mutant animals.

The long bone phenotype observed in the talpid 3 mouse is more akin to Ihh mutants and does not resemble PCP mutants, which are able to form columnar chondrocytes however they are misaligned.

There were no significant differences in osteoclast number per bone length or resorption-related parameters between control and Nrf2−/− mice at any of the indicated ages, suggesting that an osteoblast defect was primarily responsible for the reduced bone phenotype observed in vivo.

For Lrp5, Sost, Wnt10b, Dkk1 and Sfrp4 bone phenotypes observed in the HTS were confirmed and extended in subsequent cohorts of mice.

Therefore, although enhanced mechanosensory responsiveness may contribute to the cortical bone phenotype observed, this is not generally explained by activating mutations in LRP5.

The high bone mass phenotype observed in the PRKO mice and in the WT female mice treated with RU486 was associated with increased bone formation in comparison to the WT control group.

Selective inhibition of the nPR with RU486 in female mice, partially reproduced the higher bone mass phenotype observed in the PRKO female mice.

In order to determine whether the bone anabolic phenotype observed in NPY −/− mice is wholly due to the lack of hypothalamic NPY signaling, an additional transgenic mouse model was generated where NPY expression was restricted solely to the hypothalamus.

Indeed, the decrease in osteoclast number and activity observed in Lmna−/− mice could be due to either lower number of osteoblast precursors, which are the major source of RANK-L in bone, or to the aberrant osteoclast phenotype observed in Lmna−/− mice.