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Analysis of the topology of the connected bone networks showed that A and B6 mice transfer load through trabecular pathways in the middle of the vertebral body in addition to the cortical shell.
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New bone tissue formed by DPPSCs was in perfect continuity with the trabecular host bone structure, and the restored bone network demonstrated high interconnectivity.
The structural integrity of trabecular bone is an important factor characterizing the biomechanical strength of the vertebra, and is determined by the connectivity of the bone network and the trabeculation pattern.
In comparison, control mice exhibited a severely reduced and more separated trabecular bone network, similar to that of Id1−/− mice.
The texture of binarized MRI images reflected bone network directly.
Better the connection of trabecular bone network, lower the value.
Therefore, we used a network constructed from the adipose tissue to represent the bone network.
It could even be negative in a highly connective trabecular bone network [ 25].
It may reflect the connection degree of the complex trabecular bone network microstructure.
If the value of Euler number is higher, it indicates poorer trabecular bone network connectivity.
Characteristics of the trabecular bone network and the surrounding cortex served as confirmation (Fig. 2 a, c and e).
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CEO of Professional Science Editing for Scientists @ prosciediting.com