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However, to enhance reproducibility of the results, homogeneous synthetic bone models were used in place of cadaveric human vertebra of varying bone mineral densities.
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A limitation of this first biomechanical study on the use of 3 nails is that a synthetic bone model was used, which cannot precisely reproduce all in-vivo conditions.
The following models were used.
Critical sized bone defect (CSBD) animal models are used to evaluate and confirm efficacy and potency of new treatment modalities based on bone tissue engineering before the latter can be applied in clinical practice.
Artificial materials such as acrylic resin, polyurethane, or plastic bone models were commonly used as embedded "bone" implants in validation experiments.
In addition, a mouse ectopic and rat calvarial bone defect model was used to examine the feasibility of current platform to induce osteogenesis as well as bone regeneration.
An accelerated sequential proximal femoral bone loss model was used to measure the initial stability of three noncemented femoral stem designs: fully porous-coated, proximally porous-coated, and dual-tapered, diaphyseal press-fit (N = 18).
For the evaluation of bone and blood vessel formation with micro-computed tomography (micro-CT) and for the histological and immunohistochemical analyses, a rat calvarial bone defect model was used.
Rabbit radius bone defect modeling was used in this experiment.
For this study, a unicortical bone defect model was used in rat femora, in which the defect site was filled with a polycaprolactone (PCL) scaffold containing 5-LO inhibitor or carrier.
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