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The mechanical environment enhances the development of bone tissue engineered construct, which recreates the process of bone modeling.
We questioned the difference in bone modeling response the implants provoked and if it could lead to premature bone fracture.
Intermittent administration of parathyroid hormone (PTH) induces bone remodeling and renewed bone modeling, resulting in net bone gain.
Therefore the bone modeling adaptation as a method may be applied to promote the development of bone tissue engineered construct in vitro.
The initial bone modeling around implants within the first year after insertion presents a challenging topic in current research.
X-ray examinations revealed diffuse osteosclerosis, affecting spine, pelvis and long bones with bone modeling defects at the metaphyses (Fig. 1).
Bone morphogenetic proteins (BMPs) are potent osteogenic agents that induce differentiation of mesenchymal cells toward an osteoblastic lineage and stimulate the differentiation and functions of osteoblasts during a process of bone modeling [4] [6].
Mechanical forces have been described as a factor in regulating bone modeling [ 5].
As a consequence, the bone modeling processes are differently affected in answering induced biochemical osteoporosis.
In addition, VC treatment also normalized the bone strength and composition of collagen cross-links, without aberrant bone modeling [ 21].
These results may suggest that EPF via its positive effect on bone might also somewhat induce bone modeling.
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