Sentence examples for bone milieu from inspiring English sources
Bone milieu and bone marrow get detached by the lining cells at a concentration a bit higher than its solvability.
Hence, migration towards rRANKL represents migration towards the bone milieu, which constitutes the initial stage of osteoclast formation.
Moreover, pHSP27 can increase monocyte migration towards the bone milieu which may play a pivotal role in pathogenesis of osteoporosis.
Effect of pHSP27 in monocyte migration towards bone milieu can result in increased osteoclast formation and thus contribute to pathogenesis of osteoporosis.
DOI: http://dx.doi.org/10.7554/eLife.07217.004 In the bone milieu, osteoblasts and osteocytes provide RANKL and the RANKL decoy receptor OPG to stimulate and inhibit osteoclast differentiation, respectively (Boyce and Xing, 2007).
We report significant increases in the levels of interstitial cellular infiltrates and pro-inflammatory cytokines such as interleukin-17 (IL-17), interleukin-6 (IL-6), Pro- Matrix metallopeptidase 9 (Pro-MMP9), insulin like growth factor-II (GF-II) and macrophage colony stimulating factor (M-CSF) in the arthritic lung and bone milieu as well as in the circulation.
That the bone marrow milieu is hypoxic in nature is of particular relevance.
In addition, MM cells are located in the bone marrow milieu, which is usually considered hypoxic compared with other organs.
However, while the influence of bone marrow milieu in malignant hematopoietic disorders is well studied 8, the role of serous cavities, and specifically the mesothelium, in initiation and progression of body cavity lymphomas has not yet been elucidated in depth.
Recently, it has been proposed that the progressive accumulation of adipocytes and their secreted factors within the bone marrow milieu could exert a toxic effect on other cells in their vicinity (Payne et al., 2007).
Patients who miss dialysis are more likely to have poor control of their anemia, bone mineral milieu and blood pressure, more severe electrolyte imbalance with resultant life-threatening arrhythmias and recurrent volume overload.
