Sentence examples for bone microenvironment to from inspiring English sources

Multiple tumor-secreted factors act on the bone microenvironment to drive a feed-forward cycle of tumor growth.

Similarly, TGFβ interacts with the bone microenvironment to enhance breast cancer metastasis [ 47, 48].

MMP2 was also found to regulate the ERK signaling cascade and so adjust the bone microenvironment to favor osteoclastogenesis and bone metastasis.

Osteoclasts are derived from the macrophage lineage and are activated at the bone surface by cytokines and hormones in the bone microenvironment to resorb bone.

This finding lends support to the notion that breast cancer cells may use the endosteal niche, which preexists within the bone microenvironment, to colonize the bone [ 45].

For example, it could be argued that the dose of the anti-huRANKL MAb (5 mg/kg) resulted in insufficient levels of the MAb in the tumor-bone microenvironment to inhibit huRANKL-mediated osteolysis.

Tumour cells arriving in this modified bone microenvironment appeared to preferentially locate to osteoblast-rich areas, supporting that osteoblasts may be key components of the bone metastasis niche and therefore a potential therapeutic target in breast cancer.

In the osteolytic response, the attention has been predominantly focused on extracellular factors and signaling pathways that mediate the crosstalk between tumor cells and the bone microenvironment leading to the vicious cycle of tumor proliferation and bone resorption [25].

Specific aspects of breast cancer cells, tumor stroma, and the bone microenvironment contribute to the development of bone metastasis.

Moreover, TGF β released in the bone microenvironment appears to stimulate bone metastases by inducing proosteolytic gene expression in osteotropic cancer cells.

HGF is critical both locally in the bone microenvironment, due to paracrine (stroma cells) and autocrine (metastasis) production, and systemically because of the elevated levels in the bloodstream.