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Indeed, the bone microenvironment is characterized for the simultaneous presence of proinflammatory and anti-inflammatory mediators and cells.
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Tumor microenvironment is characterized by insufficient vascularization, hypoxia, acidosis, increased glucose metabolism, and aberrant protein folding.
The effect of CAIX on tumor microenvironment is characterized by the regulation of pH.
The tumor microenvironment is characterized by poor vascularization, resulting in tissue hypoxia and acidosis.
The OC microenvironment is characterized by a dramatic increase in immunosuppressive cytokines, such as TNF-α and IL-6 [ 46].
The bone microenvironment is composed of niches that house cells across variable oxygen tensions.
The bone microenvironment is also hypoxic [19].
Moreover, the bone microenvironment is known to support tumor growth in leukemia, myeloma and solid tumor bone metastasis [10], [11], [12], [13].
The preferential proliferation of cancer cells in the bone microenvironment is poorly characterised.
It is now generally accepted that the bone microenvironment is critical to the colonization and growth or dormancy of metastases.
It is also unknown whether ligands in the bone microenvironment are subjected to change in different physiological conditions.
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