Sentence examples for bone microenvironment is from inspiring English sources

The bone microenvironment is composed of niches that house cells across variable oxygen tensions.

The bone microenvironment is also hypoxic [19].

Moreover, the bone microenvironment is known to support tumor growth in leukemia, myeloma and solid tumor bone metastasis [10], [11], [12], [13].

However, the applicability of these substrates to the bone microenvironment is limited, due to the inability to achieve a sufficiently high elastic modulus that is relevant to mineralized bone tissue.

Typically, secondary tumor formation within the bone microenvironment is considered a function of bone resorption because the degrading bone mineral matrix releases bioactive ions and growth factors critical to the proliferation of both normal and transformed cells [4], [11], [36], [37].

Although the modulus of the tissue that the cells are interacting with in the bone microenvironment is not precisely known, mineralized bone tissue is orders of magnitude more rigid than the primary site [54], and well within the range of the rigid substrates used in this study.

In this study, a novel biomimetic bone microenvironment was created by integrating hydroxyapatite (HA) and native bioactive factors deposited by osteogenic induction of human bone marrow mesenchymal stem cells (MSCs) within a cytocompatible chitosan hydrogel.

It is also unknown whether ligands in the bone microenvironment are subjected to change in different physiological conditions.

The ability of HA to affect breast cancer cell colonization and tumor growth within the bone microenvironment was next assessed.

Recently, other cells of the bone microenvironment are emerging as implicated in bone health.

High osteolytic activity of the 4 T1.2 lucellslls in vivo in the bone microenvironment was also detected.